Practice question

Question

From the following statements, match the correct statements about the mechanism of action of antibiotics given below: List I List II (A) Tetracycline (I) blocks peptidyl transferase of 80S eukaryotic ribosome but not that of 70S (bacterial, mitochondrial and chloroplast ribosomes) (B) Chloramphenicol (II) inhibits protein synthesis in (bacterial, mitochondrial and chloroplast) ribosomes by blocking peptidyl transfer; it does not affect cytosolic protein synthesis in eukaryotes (C) Cycloheximide (III) inhibits protein synthesis in bacteria by blocking the A site on the ribosome, preventing the binding of aminoacyl-tRNAs (D) Streptomycin (IV) a basic trisaccharide, causes misreading of the genetic code (in bacteria) at relatively low concentrations and inhibits initiation at high concentrations (I) blocks peptidyl transferase of 80S eukaryotic ribosome but not that of 70S (bacterial, mitochondrial and chloroplast ribosomes) (II) inhibits protein synthesis in (bacterial, mitochondrial and chloroplast) ribosomes by blocking peptidyl transfer; it does not affect cytosolic protein synthesis in eukaryotes (III) inhibits protein synthesis in bacteria by blocking the A site on the ribosome, preventing the binding of aminoacyl-tRNAs (IV) a basic trisaccharide, causes misreading of the genetic code (in bacteria) at relatively low concentrations and inhibits initiation at high concentrations