Major limitation of newly synthesized allopolyploids is:
Newly synthesized allopolyploids face meiotic irregularities despite possession of homologous sets because homoeologous chromosomes from related parental genomes may still pair multivalently when Ph-like controls absent, leading to interchanges, aneuploid gametes, and reduced pollen viability. Genomic shock disrupts gene regulation: duplicate homoeologs exhibit expression bias, silencing, and epigenetic repatterning through methylation changes, small RNA perturbations, and transposon mobilization, causing phenotypic instability and transcriptome shock. Initial polyploids often show low seed fe
Ref: McClintock B. Genomic shock; Otto & Whitton 2000 Annual Rev Genetics – limitations of synthetic polyploids
