Practice question
Question
Which rRNA is part of large subunit in prokaryotes?
Explanation
The bacterial 70S ribosome consists of 30S small subunit and 50S large subunit. The large subunit comprises 23S rRNA of about 2900 nucleotides and 5S rRNA plus 33 ribosomal proteins. 23S rRNA dominates the particle, forming peptidyl transferase center in domain V, nascent peptide exit tunnel lining, and intersubunit bridges. 16S rRNA is confined to small subunit for decoding. Therefore, 23S marks the large subunit, whereas 16S marks small subunit. Eukaryotic counterpart is 28S rRNA in 60S, underscoring evolutionary conservation of large subunit catalytic RNA.
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