Practice question
Question
RNase P functions in processing of
Explanation
Primary conserved function of RNase P across bacteria, archaea and eukarya is 5' maturation of precursor tRNAs. tRNA genes produce longer precursors with 5' leader sequences that must be removed to create mature cloverleaf with correct acceptor stem length for aminoacylation. RNase P introduces precise endonucleolytic cut at leader-tRNA junction, leaving 5' phosphate. It also processes polycistronic operons, some rRNA precursors, and tmRNA, but tRNA processing defines its essential housekeeping role; mitochondrial human RNase P evolved to protein-only form MRPP complex yet retains same cleavage specificity.
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