Practice question
Question
Which rRNA interacts with Shine–Dalgarno sequence?
Explanation
Shine-Dalgarno sequence AGGAGG located five to nine nucleotides upstream of start codon in bacterial mRNA base-pairs with anti-Shine-Dalgarno CCUCCU at 3' terminus of 16S rRNA in 30S subunit. This RNA-RNA duplex anchors mRNA on ribosome, aligns AUG in P-site for initiator tRNA binding, facilitating 30S pre-initiation complex formation. Strength of pairing modulates translation initiation efficiency across cistrons in polycistronic mRNAs. Eukaryotes lack Shine-Dalgarno, using 5' cap and Kozak context for scanning-dependent initiation instead of internal base-pairing mechanism. This refined regulation supports accurate ribosomal assembly, quality control and translational fidelity under diverse physiological conditions and growth states.
Related blogs
Guides and insights connected to this topic
SARS-CoV-2 Coronavirus: Structure, Genome, Proteins, Replication, Pathogenesis, and Host Interaction
Coronavirus Overview Coronaviruses (CoVs) are enveloped viruses (surrounded by a lipid membrane derived from host cells), belonging to the s...
Coronavirus Structure, Genome, Replication, Symptoms, Pathogenesis, and Prevention
Structure of Coronavirus Coronaviruses (enveloped RNA viruses) fall in the virus family Coronaviridae, order Nidovirales. They are enveloped...
Cucumber Mosaic Virus (CMV): Structure, Genome, Symptoms, Disease Cycle and Management
Cucumber Mosaic Virus (CMV): Introduction and Importance Cucumber Mosaic Virus (CMV) (plant-infecting RNA virus) is one of the most economic...