Practice question
Question
DNA polymerase V is part of
Explanation
Severe DNA damage causes accumulation of single-stranded DNA activating RecA to stimulate autocleavage of LexA repressor derepressing over 40 SOS genes regulon. Among strongly induced are umuD and umuC genes encoding Pol V, Y-family error-prone polymerase capable of copying past pyrimidine dimers that block Pol III. Pol V requires RecA nucleoprotein filament for activation as mutasome complex. Its expression relatively late in SOS response provides last-resort translesion synthesis when excision repair incomplete enabling survival despite persisting lesions but dramatically increasing mutation rate.
Related blogs
Guides and insights connected to this topic
SARS-CoV-2 Coronavirus: Structure, Genome, Proteins, Replication, Pathogenesis, and Host Interaction
Coronavirus Overview Coronaviruses (CoVs) are enveloped viruses (surrounded by a lipid membrane derived from host cells), belonging to the s...
Coronavirus Structure, Genome, Replication, Symptoms, Pathogenesis, and Prevention
Structure of Coronavirus Coronaviruses (enveloped RNA viruses) fall in the virus family Coronaviridae, order Nidovirales. They are enveloped...
Cucumber Mosaic Virus (CMV): Structure, Genome, Symptoms, Disease Cycle and Management
Cucumber Mosaic Virus (CMV): Introduction and Importance Cucumber Mosaic Virus (CMV) (plant-infecting RNA virus) is one of the most economic...