Practice question
Question
Decatenation of daughter chromosomes is done by
Explanation
After circular chromosome duplication, two daughter molecules become interlinked as catenanes resembling linked rings generated naturally during replication termination and intertwining. Topoisomerase IV, type II topoisomerase of ParC and ParE subunits as C2E2 tetramer, performs decatenation by introducing transient double-strand breaks in one duplex, passing other duplex through opening, and resealing using ATP hydrolysis energy. DNA gyrase primarily introduces supercoils, topoisomerase I relaxes negative supercoils but cannot decatenate due to single-strand mechanism. Topo IV activity essential for chromosome segregation before cell division.
Related blogs
Guides and insights connected to this topic
SARS-CoV-2 Coronavirus: Structure, Genome, Proteins, Replication, Pathogenesis, and Host Interaction
Coronavirus Overview Coronaviruses (CoVs) are enveloped viruses (surrounded by a lipid membrane derived from host cells), belonging to the s...
Coronavirus Structure, Genome, Replication, Symptoms, Pathogenesis, and Prevention
Structure of Coronavirus Coronaviruses (enveloped RNA viruses) fall in the virus family Coronaviridae, order Nidovirales. They are enveloped...
Cucumber Mosaic Virus (CMV): Structure, Genome, Symptoms, Disease Cycle and Management
Cucumber Mosaic Virus (CMV): Introduction and Importance Cucumber Mosaic Virus (CMV) (plant-infecting RNA virus) is one of the most economic...