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#Sox2

2 public questions tagged with this topic.

Fertilization in mammals-ll

Oct4, Sox2, Nanog maintain pluripotency in:

Pluripotency of inner cell mass and derived embryonic stem cells depends on core transcription factor circuit Oct4 Sox2 Nanog forming feed-forward autoregulatory loop. These factors co-bind promoters of self-renewal genes while repressing differentiation drivers like Cdx2 and Gata6 via chromatin remodeling. Active Hippo pathway retaining YAP cytoplasmically permits sustained expression. Withdrawal of any component collapses pluripotency causing precocious trophectoderm or primitive endoderm differentiation. Triad therefore maintains naive state ensuring capability to generate all embryonic lineages upon gastrulation signals, implantation cues, developmental progression and differentiation stimuli in embryogenesis.

Ref: Young, Molecular Biology of Stem Cells: Oct4, Sox2, Nanog core pluripotency circuit in ICM and ES cells.

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Fertilization in mammals-iv

Pluripotency maintained by:

Pluripotency of inner cell mass and embryonic stem cells is maintained by core transcriptional network centered on Oct4, Sox2 and Nanog. These factors co-occupy enhancers of self-renewal genes while repressing lineage-specific differentiation genes via chromatin remodeling. Oct4 and Sox2 form heterodimer activating Nanog promoter, and all three autoregulate and cross-regulate each other creating robust circuit. Stat3 downstream of LIF supports mouse pluripotency but alone insufficient. Nanog alone cannot sustain, nor can FoxA2/Gata6 which actually promote primitive endoderm differentiation, opposing pluripotent state and triggering exit toward differentiated lineages.

Ref: Yamanaka et al., Nature 2006; Gilbert Ch 6: Core pluripotency network Oct4 Sox2 Nanog maintaining embryonic stem cells.

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