Necroptosis is commonly triggered when
Necroptosis is a regulated form of necrotic cell death that occurs when caspase-8 is inhibited or absent. Under these conditions the kinase RIPK1 activates RIPK3, which in turn phosphorylates MLKL. Oligomerized MLKL disrupts plasma-membrane integrity, producing a necrotic morphology. Necroptosis therefore serves as a backup death pathway when apoptosis is blocked, particularly during certain viral infections.
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)