Which of the following morphogens is involved in neural crest migration?
Neural crest specification and migration rely on coordinated Wnt and BMP signaling at neural plate border. Canonical Wnt6 from non-neural ectoderm plus intermediate BMP activate border factors Snail2, FoxD3, Sox9 defining premigratory crest. Wnt signaling activates beta-catenin transcription of Slug promoting epithelial-mesenchymal transition, delamination and acquisition of migratory machinery including integrins and metalloproteinases. Post-delamination, Wnt guides directional migration and proliferation of crest derivatives. BMP4 contributes to delamination but primary motility driver is Wnt, while Myosin motor and fibronectin matrix provide mechanical execution rather than morphogen instruction.
Ref: Mayor and Theveneau, Development 2013, Wnt Signaling in Neural Crest Migration.