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#medical microbiology

11 public questions tagged with this topic.

Which phylum includes Helicobacter pylori?

Helicobacter pylori represents microaerophilic curved Gram-negative bacterium classified within class Epsilonproteobacteria of phylum Proteobacteria based on 16S rRNA phylogeny, unipolar flagellation, and microaerophilic physiology. It colonizes human gastric mucosa using urease producing ammonia to neutralize gastric acid, adhesins and cytotoxins CagA and VacA triggering inflammation. Strong association with chronic gastritis, peptic ulcers, and gastric adenocarcinoma established it as type species of Helicobacter. Its proteobacterial affiliation contrasts with Spirochaetes, Firmicutes, and Actinobacteria, clustering near Campylobacter within epsilon subgroup recognized in molecular taxonomy.

Ref: Tortora Microbiology 12th ed., Chapter 11 Epsilonproteobacteria Helicobacter; Bergey's Manual Volume 2 Proteobacteria Helicobacter pylori gastric

Treponema pallidum causes

Treponema pallidum subspecies pallidum is a fastidious microaerophilic spirochete exhibiting distinctive corkscrew morphology with endoflagella located within periplasmic space between outer membrane and cytoplasmic cylinder, driving motility in viscous environments like mucosal secretions. Unable to be continuously cultured in vitro, it transmits via sexual contact causing syphilis characterized by primary chancre, secondary disseminated rash, and tertiary gummas, cardiovascular and neural damage. Taxonomic placement in family Spirochaetaceae reflects helical coiling, outer sheath lacking lipopolysaccharide, and diagnosis requiring dark-field microscopy and serological treponemal tests.

Ref: CDC Syphilis Treponema pallidum spirochete; Jawetz Medical Microbiology 27th ed., Spirochaetes Treponema morphology dark-field