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#chromosome structure

3 public questions tagged with this topic.

Pericentric inversion includes

Pericentric inversion includes centromere within inverted interval, so breakpoints lie on opposite arms: one in short arm p and one in long arm q. Reorientation moves centromere position, altering arm ratio and possibly changing metacentric to submetacentric morphology. This change can be detected cytogenetically as altered p/q length. In heterozygotes, pairing forms inversion loop to align homologous sequences, and single crossover inside loop yields chromatids with duplication and deletion of terminal segments, leading to unbalanced gametes and risk for recombinant offspring with clinical abnormalities.

Ref: Hartl & Jones, Genetics, 8th ed., Chapter 12: Inversion Mechanics; Griffiths Chapter 8

p arm of chromosome is:

Chromosome morphology nomenclature describes arms relative to primary constriction. Short arm designated p for petite in French, long arm designated q following alphabetical convention. Metacentric, submetacentric and acrocentric classification depends on centromere position determining p to q length ratio. G-banding pattern allows identification of p versus q. Acrocentric p arms often contain satellite stalks and nucleolar organizer regions with rDNA clusters. Genetic loci notation like 17p13.1 refers to band on short arm. Therefore p arm terminology indicates morphological short arm, distinct from centromere core or heterochromatic satellite itself.

Ref: Gardner et al., Chromosome Biology Nomenclature; Mitelman, Chromosome Arms p Short and q Long