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#biology preparation

18 public questions tagged with this topic.

Linker histone associated with chromatosome is:

Linker DNA connecting adjacent nucleosomes constitutes binding site for fifth histone family distinct from core. H1 binds at dyad axis where DNA enters and exits octamer, globular winged-helix domain contacts both linkers while lysine-rich C-terminal tail neutralizes linker DNA charge. Interaction seals nucleosome, determines exit angle and promotes 30 nanometer fiber folding into solenoid or zigzag conformations. Core histones H2A, H2B, H3 remain buried inside octamer forming handshake motifs, not contacting linker extensively. Therefore H1 classifies as linker histone easily extracted at moderate salt 0.5 molar versus core.

Ref: Allan et al., J Mol Biol 1980; Alberts et al., Molecular Biology of the Cell, Chapter 4: Linker Histone H1 Chromatosome

Constitutively active growth factor receptors generally act in a

Dominant manner, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Normal cells require serum growth factors mainly to

Enter cell cycle, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Normal cells stop dividing upon cell–cell contact due to

Contact inhibition, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)