Practice question
Question
Which cytokine induces antiviral state via STAT1/STAT2?
Explanation
Type-I interferons (IFN-α and IFN-β) are rapidly induced during viral infection and act in both autocrine and paracrine fashion. Binding to the IFNAR receptor activates STAT1/STAT2 and IRF9, which induce hundreds of interferon-stimulated genes that establish an antiviral state, inhibit viral replication and enhance antigen presentation. This response is a cornerstone of innate antiviral immunity.
Related blogs
Guides and insights connected to this topic
SARS-CoV-2 Coronavirus: Structure, Genome, Proteins, Replication, Pathogenesis, and Host Interaction
Coronavirus Overview Coronaviruses (CoVs) are enveloped viruses (surrounded by a lipid membrane derived from host cells), belonging to the s...
Coronavirus Structure, Genome, Replication, Symptoms, Pathogenesis, and Prevention
Structure of Coronavirus Coronaviruses (enveloped RNA viruses) fall in the virus family Coronaviridae, order Nidovirales. They are enveloped...
Cucumber Mosaic Virus (CMV): Structure, Genome, Symptoms, Disease Cycle and Management
Cucumber Mosaic Virus (CMV): Introduction and Importance Cucumber Mosaic Virus (CMV) (plant-infecting RNA virus) is one of the most economic...