Practice question
Question
Rb protein prevents S-phase entry by binding to
Explanation
Hypophosphorylated Rb binds and represses E2F transcription factors, preventing expression of genes required for S-phase entry. Mitogenic signaling activates cyclin-D–CDK4/6 and cyclin-E–CDK2 complexes that progressively phosphorylate Rb. Hyperphosphorylated Rb releases E2F, allowing S-phase progression. Loss of Rb function therefore removes a critical G1 checkpoint and contributes to uncontrolled proliferation. Careful
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