Practice question
Question
Primary role of Kozak sequence is
Explanation
Surrounding the initiator AUG in vertebrate mRNAs, the consensus GCCRCCAUGG described by Marilyn Kozak provides sequence context that modulates initiation efficiency beyond start codon alone. Positions -3 purine and +4 guanine contact 18S rRNA nucleotides and eIF2alpha subunit, stabilizing codon-anticodon pairing in the P-site and slowing scanning to favor GTP hydrolysis by eIF5 and commitment to 48S complex. Strong Kozak context improves accurate start recognition and reduces leaky scanning to downstream AUGs. Elements governing termination, elongation continuation, and ribosome recycling are distinct from this initiation signal that controls start site selection.
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