Practice question

Nullisomy notation describes loss both copies homologous chromosome pair completely missing from diploid nucleus, diploid number reduces by two following formula 2n -2 where 2n diploid normal. Example humans normally 46 chromosomes, nullisomy for any autosome would leave 44 chromosomes and absence essential genes. Condition generally incompatible with viability in diploid organisms because many essential genes absent in zero copies causing early embryonic failure, unless organism polyploid where compensating genomes exist like hexaploid wheat where nullisomy stocks viable and used for chromosome assignment research. Represents extreme hypoploidy compared monosomy.