Practice question

In pedigree analysis of late-onset autosomal disorders, linked RFLP alleles cosegregate with the disease mutation due to physical proximity on the chromosome, reducing recombination. Affected parents transmit the disease-associated restriction fragment to progeny. Grandchildren inheriting that specific fragment exhibit the disease phenotype, while those receiving alternative fragment remain unaffected. Recombination between marker and disease locus could break association, but tightly linked markers show minimal recombinant proportion. This principle enables predictive testing and tracking of mutant haplotypes through generations using Southern hybridization patterns.