Practice question
Question
43S pre-initiation complex contains
Explanation
Eukaryotic 43S pre-initiation complex represents key intermediate before mRNA recruitment, comprising 40S small subunit bound to eIF1, eIF1A, eIF3 multi-subunit complex, eIF5, and ternary complex eIF2 GTP Met-tRNAiMet positioned in P site. Assembly occurs independently of mRNA and ensures initiator tRNA ready to base-pair with start codon. This complex interacts with eIF4F capped mRNA to form 48S scanning complex. Formation of ternary complex is rate-limiting regulated by eIF2 alpha phosphorylation during integrated stress response reducing global initiation while permitting selective ATF4 translation.
Related blogs
Guides and insights connected to this topic
SARS-CoV-2 Coronavirus: Structure, Genome, Proteins, Replication, Pathogenesis, and Host Interaction
Coronavirus Overview Coronaviruses (CoVs) are enveloped viruses (surrounded by a lipid membrane derived from host cells), belonging to the s...
Coronavirus Structure, Genome, Replication, Symptoms, Pathogenesis, and Prevention
Structure of Coronavirus Coronaviruses (enveloped RNA viruses) fall in the virus family Coronaviridae, order Nidovirales. They are enveloped...
Cucumber Mosaic Virus (CMV): Structure, Genome, Symptoms, Disease Cycle and Management
Cucumber Mosaic Virus (CMV): Introduction and Importance Cucumber Mosaic Virus (CMV) (plant-infecting RNA virus) is one of the most economic...