Practice question
Question
SWI/SNF complex is involved in:
Explanation
Chromatin structure generally impedes transcription factor binding, requiring active remodeling. ATP-dependent remodeling complexes utilize energy from ATP hydrolysis to slide, evict or restructure nucleosomes exposing DNA. SWI/SNF family, containing BRG1 or BRM ATPase, disrupts histone-DNA contacts creating nucleosome-depleted regions at enhancers and promoters, essential for inducible transcription activation and DNA repair. Mutations in SWI/SNF subunits drive rhabdoid tumors and other cancers. It cooperates with histone acetylation opening chromatin, contrasting with ISWI and CHD families spacing nucleosomes regularly. SWI/SNF governs accessibility rather than histone synthesis.
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