Practice question
Question
In a biosynthetic pathway A → B → C → D → E, a mutant blocked at step C→D will grow when supplemented with
Explanation
Linear pathway A to E ordered by observing which supplements rescue growth of mutant blocked between C and D, applying bypass logic. Upstream intermediates A and B require functional conversion through blocked enzyme so they fail to restore growth because defect remains. Downstream products D and E bypass defect directly supplying end product for protein synthesis. Some textbooks include immediate precursor C as rescuing if accumulation drives leaky activity but principle remains downstream rescue indicates block position. Counting rescued mutants per supplement allows sequential arrangement of metabolites reflecting enzyme order along chromosome.
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