Practice question
Question
CENP-A is a variant of histone:
Explanation
Centromeric chromatin contains distinctive histone variant CENP-A that epigenetically specifies centromere location independent of underlying DNA sequence in most eukaryotes. CENP-A resembles canonical histone H3 in histone fold domain sharing about sixty percent similarity, but possesses divergent N-terminus and loop1 centromere targeting domain CATD directing specific deposition via HJURP chaperone during G1. It replaces H3 in subset of nucleosomes at active centromere creating specialized octamer recruiting inner kinetochore. H1 is linker histone, H2A variants include H2A.Z, H4 lacks centromeric-specific variant analogous to CENP-A functionally.
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