Practice question

High-throughput genotyping demands markers that are extremely abundant, evenly distributed across chromosomes, biallelic, easily automated and suitable for multiplexed detection in parallel reactions. Single Nucleotide Polymorphisms fulfill these requirements with occurrence every few hundred bases, amenable to array-based chips, next-generation sequencing and fluorescence-based assays producing millions of genotypes rapidly with minimal DNA input. SSR, VNTR and RAPD rely on gel electrophoresis and manual allele sizing, limiting throughput and automation. SNP platforms offer cost-effective scalable screening for association studies and genomic selection programs.