Practice question
Question
In the pedigree showing STRs A-B-C on X-chromosome, recombination is found in:
Explanation
X-chromosome STRs A-B-C are transmitted as haplotypes with limited recombination due to hemizygosity in males and sequential inheritance. In pedigree analysis, deviation from expected maternal transmission indicates crossover between markers. When offspring III-2 and III-4 display new allelic combinations of A-B-C not present in either maternal chromosome, recombination between those loci must have occurred during maternal meiosis I or II. Other individuals retain parental haplotypes unchanged. Detecting such recombination events allows estimation of genetic distance and linkage analysis, demonstrating meiotic exchange on X chromosome during gamete formation in pedigree.
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