Practice question
Question
Map distance between two genes in unordered tetrad analysis is calculated using
Explanation
Map distance in unordered tetrads converts tetrad frequencies to recombination fraction based on proportion recombinant chromatids among all chromatids scored. Tetratype ascus contains half recombinant chromatids, nonparental ditype contains all four recombinant chromatids fully recombinant. Simplest formula RF = (TT/2 + NPD)/total tetrads multiplied by 100 gives centimorgan estimate for moderate distances under 30 cM. More accurate mapping including multiple crossover correction uses (TT +6 NPD)/2×total or (TT/2 +3 NPD)/total because NPD may arise from multiple exchange types. Simpler version sufficient for introductory genetics problems.
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