Practice question
Question
Kinetochore assembles at:
Explanation
Kinetochore is large multiprotein structure assembling exclusively at centromeric chromatin containing CENP-A nucleosomes. During mitosis inner kinetochore components CENP-C, CENP-T, CENP-I constitutively associate with centromere, outer KMN network including Ndc80, Mis12, KNL1 complexes binds plus ends of spindle microtubules. This linkage transmits pulling forces to separate sister chromatids and activates spindle assembly checkpoint via Mad2, BubR1 until biorientation achieved. Telomeres cap ends, replication origins fire throughout genome, NORs build nucleolus, whereas kinetochore location solely defines segregation platform at centromere region.
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