Practice question
Question
Intracellular receptors often act as
Explanation
Many intracellular receptors for hydrophobic ligands belong to the nuclear-receptor superfamily. Upon ligand binding they undergo conformational changes that enable DNA binding and recruitment of co-activators or co-repressors, thereby regulating transcription of specific target genes. This direct genomic mode of action accounts for the relatively slow but long-lasting effects of steroid and thyroid hormones.
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