Practice question
Question
Why do endothelial cells lacking VE-cadherin fail to survive despite N-cadherin adhesion? (Dec 2013)
Explanation
VE-cadherin acts as co-receptor for VEGF signaling, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.
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