Practice question

A transcriptome microarray, also called expression array, contains probes for all annotated genes or entire transcriptome represented as tens of thousands of spots on a chip. Single hybridization of labeled cDNA from experimental and control samples allows parallel assessment of expression differences. Statistical analysis identifies hundreds to thousands of differentially expressed genes by fold change and p-value. RAPD assesses DNA polymorphism, genome sequencing determines DNA sequence rather than expression levels, and ChIP assesses protein-DNA interactions, making them unsuitable for simultaneous high-throughput quantification of over a thousand expression changes.