Practice question
Question
Which repeat is found in telomeric regions?
Explanation
Repetitive DNA localization reflects functional specialization of chromosome domains. Minisatellites, classified as VNTRs with 10-100 bp units, frequently cluster in subtelomeric and terminal regions, contributing to telomere stability, recombination hotspots and chromosome pairing during meiosis. Macrosatellites also reside at centromeres and heterochromatic blocks. SSRs and STRs, representing microsatellites with 1-6 bp motifs, are interspersed throughout euchromatin rather than enriched at ends. Preferential accumulation of minisatellite arrays near telomeres supports their structural role in maintaining chromosome integrity and regulating recombination frequency.
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