Practice question

Patrick O. Brown, at Stanford University, introduced the concept of printing defined DNAs onto glass slides via robotic spotting in 1995. His laboratory demonstrated that differently labeled cDNAs from two samples could competitively hybridize to such arrays to quantify differential gene expression genome-wide. This innovation founded modern transcriptomics, enabling simultaneous monitoring of thousands of genes, shifting paradigm from single-gene northern blots. Fluorescence In Situ Hybridization, RNA sequencing, and CGH were developed by different groups focusing on cytogenetics and sequencing, not array-based expression profiling credited to Brown.