Practice question
Question
TLR4 primarily recognizes
Explanation
Toll-like receptor 4, in complex with MD-2, is the primary sensor for bacterial lipopolysaccharide. Ligand binding triggers both MyD88-dependent and TRIF-dependent signaling pathways that culminate in NF-κB activation and type-I interferon production. The resulting inflammatory response is essential for host defense yet can also drive septic shock when excessive. Careful
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