Practice question
Question
Smac/DIABLO promotes apoptosis by
Explanation
XIAP is a potent inhibitor of caspases-3, -7 and -9. The mitochondrial protein Smac/DIABLO, released during MOMP, binds XIAP and neutralizes its inhibitory activity, thereby facilitating full activation of the caspase cascade. This dual control—release of both cytochrome c and Smac—ensures robust commitment to apoptosis once mitochondria are permeabilized. Careful
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