Practice question
Question
NK cell-mediated killing involves release of
Explanation
Natural killer cells survey the surface of potential target cells for the presence of MHC class I molecules. Cells that lack or down-regulate MHC I, a common strategy of viruses and tumors, are recognized as missing-self and are killed by release of perforin and granzymes. NK cells therefore provide an important innate barrier against transformed and virally infected cells.
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