Practice question
Question
Cholera toxin causes diarrhea by:
Explanation
Cholera toxin catalyzes ADP-ribosylation of Gαs, locking the subunit in its GTP-bound active form by inhibiting GTPase activity. Persistent activation of adenylyl cyclase produces massive elevations of cAMP in intestinal epithelial cells, leading to continuous opening of chloride channels and the characteristic watery diarrhea of cholera. Careful
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