Practice question
Question
The apoptosome is composed of
Explanation
Mitochondrial outer-membrane permeabilization (MOMP) releases cytochrome c into the cytosol. Cytochrome c binds Apaf-1, inducing formation of the heptameric apoptosome that recruits and activates caspase-9. Active caspase-9 then propagates the cascade by cleaving executioner caspases. MOMP is therefore the point of no return for the intrinsic apoptotic pathway. Careful
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