Practice question
Question
Pertussis toxin causes increased cAMP because it
Explanation
Pertussis toxin ADP-ribosylates Gαi, preventing the inhibitory G protein from interacting with receptors and thereby blocking its ability to inhibit adenylyl cyclase. The resulting loss of tonic inhibition elevates cAMP levels and contributes to the pathogenesis of whooping cough. The toxin has also become a valuable experimental tool for identifying Gi-coupled pathways.
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