Practice question
Question
p53 induces apoptosis mainly via activation of
Explanation
The tumor-suppressor protein p53 is kept at low levels in unstressed cells by continuous MDM2-mediated ubiquitination and degradation. DNA damage or oncogenic stress leads to phosphorylation of p53 or induction of ARF, both of which block the p53–MDM2 interaction. Stabilized p53 then transcriptionally activates genes that induce cell-cycle arrest, DNA repair or apoptosis, thereby preventing propagation of damaged genomes.
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