The following statements are made with reference to membrane fusion reactions in vesicle transport catalyzed by transmembrane SNARE proteins.

The following statements are made with reference to membrane fusion reactions in vesicle transport catalyzed by transmembrane SNARE proteins.

1. The SNARE transmembrane proteins exist as complementary sets, with v-SNARES on vesicle membranes and t-SNARES on target membranes
2. A v-SNARE is usually composed of 3 proteins and t-SNARE is a single polypeptide cha
3. The v-SNARE and t-SNARE proteins of a pair interact via helical domains possessed by the two proteins, resulting in formation of a stable two-helix bundle
4. Membrane fusion is catalysed by the energy that is freed when the interacting helices wrap around each other to pull the membrane faces together, concurrently squeezing out water molecules from the interface.

Which one of the following combinations represents all correct statements?

1. 1 and 2   
2. 2 and 3
3. 3 and 4  
4. 1 and 4

✅ Correct combination

✔ Statements 1 and 4